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Acum 5 zile · Ubiquitin is a small protein that exists in all eukaryotic cells. It performs its myriad functions through conjugation to a large range of target proteins. A variety of different modifications can occur. The ubiquitin protein itself consists of 76 amino acids and has a molecular mass of about 8.6 kDa.
Acum 22 ore · Finally, 15,860 protein structures, aligning with 5473 UniProt entries, were employed for the training phase. Then we artificially select 1/10 data as the internal validation set during the training process and make sure all structures of a single protein must be in this set. This setup was necessary to avoid data leakage . Data processing
Acum 2 zile · The retrieved XML files are processed using Biopython’s UniProt parser 21, resulting in standardized and well-annotated protein entries, ultimately leading to more robust search functionality.
Acum 5 zile · C. UniProt, UniProt: the universal protein knowledgebase in 2023, Nucleic Acids Res. 51 (2023) D523–D531. Google Scholar [5]
Acum 5 zile · Alignment-based methods (e.g. BLAST 42 or HMMER 43), can be used to match individual sequences to large databases such as eggNOG, 44 InterPro, 45 UniProt 46 and KEGG, 47 which collectively encompass millions of protein families recovered from organisms belonging to all domains of life.
Acum 4 zile · UniProt: Canonical: D4A133 (Residues: 1-647; Coverage: 100%) Gene name: Atp6v1a Sequence domains: ATP synthase alpha/beta family, beta-barrel domain; ATPsynthase alpha/beta subunit N-term extension; ATP synthase alpha/beta family, nucleotide-binding domain; C-terminal domain of V and A type ATP synthase;
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