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The MRI studies that use techniques such as diffusion-tensor imaging and magnetization transfer to examine water diffusivity and the integrity of the white matter show that some of the early pathophysiologic changes also occur in white matter areas that appear normal on conventional MRI.
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First, the visual grade rating scales that are used to measure white matter lesion (WML) on CT or MRI are based on the site and the severity of white matter disease. MRI-based scales, such as the Fazekas scale, grades WML in both periventricular (PVH) and deep white matter locations (score 0–3).
4 mai 2022 · White matter disease is an umbrella term for changes and damage to your brain’s white matter — the nerve fibers in your brain that connect different areas of your brain to each other and to your spinal cord like highways.
White matter lesions at the frontal horns, so-called “capping,” are in close proximity to cholinergic axons that originate in the basal forebrain. Therefore, these lesions may result in more significant cortical deafferentation because of the more proximal axonal disruption.
1 ian. 2019 · By mapping motor, sensory, language, and cognitive function, researchers have been able to correlate the studied anatomy through dissections and DTI, with the actual function of the tract. This chapter will provide current data on the localization and function of some of the major WMTs described to date.
Diffusion-weighted imaging shows punctate areas of restriction in the deep white matter (H), and CT scan of head shows bilateral foci of calcification (I)—both characteristic of CSF1R (hereditary diffuse leukoencephalopathy with spheroids). FLAIR, fluid attenuated inversion recovery.
7 oct. 2019 · MR images show extensive white matter involvement, with multiple low-signal-intensity foci within the disseminated areas of T2 hyperintensity (pointing to hemorrhage).
